GPRC5A regulates proliferation and oxidative stress by inhibiting the STAT3/Socs3/c-‍MYC pathway in hepatocellular carcinoma

The G protein-coupled receptor, class C, group 5, member A (GPRC5A) plays a key role in various diseases, but its effect on hepatocellular carcinoma (HCC) and the potential underlying mechanisms remains unclear. In present study, we explored of GPRC5A progression HCC further mechanism action. results revealed that expression was lower tissues cells. Overexpression suppressed proliferation epithelial-mesenchymal transition (EMT) addition, overexpression induced oxidative stress apoptosis. Further study showed inhibited STAT3/Socs3/c-‍MYC related-protein NLRP3 inflammasome. Moreover, inflammasome involved These suggest suppresses EMT, induces leads to apoptosis cells, potentially by regulating signalling findings has an anti-tumor formation HCC, molecular therapy provides theoretical basis for treating HCC.